Welcome to the Johnson & Morganti Lab interactive datasets exploring the role of APOE across aging, inflammation, and AD pathology. The following datasets are comprised of i) whole brain tissue (bulk) sequencing, ii) whole brain scRNAseq, iii) microglia only scRNAseq, and iv) spatial transcriptomics. Brains from female APOE3 and APOE4 mice were analyzed across the lifespan (3, 12 and 24 months of age), and in the presence of an inflammatory challenge (LPS) or AD pathology (amyloid overexpression). For details on methodology, please see Lee, Devanney et al., 2022.
